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CAS No. 856867-55-5 | Tedizolid Phosphate

CAS No. 856867-55-5 | Tedizolid Phosphate

Name: Tedizolid Phosphate CAS No. 856867-55-5 MF:C17H16FN6O6P MW:450.32 Purity:98% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 856867-55-5 | Tedizolid Phosphate

Synonyms:[(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyldihydrogenphosphate;

TedizolidphosphateimpurityA;

(R)-3-(4-(2-(2-methyl-tetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl-oxazolidin-2-onephosphate;(R)-3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyloxazolidin-2-onephosphate;

-3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyloxazolidin-2-onephosphate;

(5R)-3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone;

TedizolidPhosphate(TR-701);

Torezolidphosphate

Specification:

ITEMS	SPECIFICATION
CAS	856867-55-5
MF	C17H16FN6O6P
MW	450.32
Melting point	>235°C
Boiling point	725.6±70.0 °C
Density	1.75±0.1 g/cm3
Acidity coefficient	1.81±0.10
Color	White to off-white
Solubility	DMSO (slightly sonicated)
Form	Solid
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C

Introduction:

Tedizolid phosphate, also known as tedizolid phosphate, tedizolid phosphate, tedizolid phosphate, tedizolid phosphate is a second-generation oxazolidine developed by Dong-APharmaceutical Phase III clinical trials of ketone antibiotics have shown that their clinical effects are equivalent to linezolid, with fewer adverse reactions in the gastrointestinal tract and thrombocytopenia than linezolid, and the incidence of drug resistance is also lower. Some trials have shown that tedizolid is also better tolerated than vancomycin. FDA-approved dosage forms include injections and tablets, which are convenient for clinical switching. The dosage is once a day for six days, and plinezolid is used twice a day for ten days, which is more convenient for clinical use. Therefore, in view of its good clinical effect, smaller dose and shorter administration period, it is suitable for a wide range of people and has a broad market capacity.

Preparation:

Under nitrogen protection, add 1.0kg (R)-3-[4-[2-(2-methyltetrazol-5-yl)pyridin-5-yl]-3-fluorophenyl]- into the reactor. 5-Hydroxymethyloxazolidine, 0.32kg triethylamine and 17.8kg tetrahydrofuran, start stirring, cool to 0°C, slowly add 2.14kg phosphorus oxychloride/tetrahydrofuran solution, complete the addition, control the temperature to 0°C, stir and react for 5 hours , take out the mixed liquid, add 20.0kg purified water to the reactor, cool to 5°C, start stirring, add the above mixed liquid, control the adding process to control the system temperature to 5°C, after the addition is completed, raise the temperature to 25°C, stir for 1 hour, and shake Filter, rinse the filter cake once with 1.0kg purified water, filter until no liquid flows out, collect the filter cake; put the filter cake into the reactor, add 5.9kg methanol and 0.7kg purified water, keep warm and stir for 0.5h, shake Filter, rinse the filter cake once with 0.7kg methanol, filter until no liquid flows out, collect the filter cake, place the filter cake in a hot air circulation drying oven, heat it to 40°C, and dry it for 4 hours to obtain tedizolid phosphate. The calculated yield is 75.68% and the purity is 99.95%.

Package and transportation :

Package: 5g,25g,200g,500g,1kg

Transportation: by courier/ by air/ by sea

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